References

6. Cystistat Instructions For Use.

24. Teva UK Ltd. Data on File. Cystistat Product Monograph. 2017.

How do I use Cystistat?

Sterile Sodium Hyaluronate Solution - for temporary replacement of the glycosaminoglycan (GAG) layer in the bladder6

DESCRIPTION

The glycosaminoglycan (GAG) layer on the luminal surface of the bladder wall is believed to provide a protective barrier against microorganisms, carcinogens, crystals and other agents present in the urine and has been identified as the primary defence mechanism in protecting the transitional epithelium from urinary irritants

Deficiencies in this GAG layer of the bladder epithelium may destroy its barrier function and allow the adherence of bacteria, microcrystals, proteins and ions, or the movement of ionic and non-ionic solute residues (i.e. urea) across the epithelium. Cystistat has been developed to temporarily replenish the GAG layer on the bladder epithelium. The active substance is a highly purified sodium salt of hyaluronic acid. Each Cystistat® vial contains: 40mg sodium hyaluronate

DIRECTIONS

Instill the entire volume of this solution into the bladder via a catheter after any residual urine has been removed. Discard any unused portion. For best results, Cystistat should be retained in the bladder for as long as possible (a minimum of 30 minutes)

There is evidence that the GAG layer of the bladder is deficient in cystitis. This deficiency contributes to the clinical symptoms in the diseases such as interstitial cystitis, cystitis caused by infections, trauma, urolithiasis, urinary retention, neoplasia and radiation induced cystitis. To alleviate cystitis associated with these conditions, it is recommended that Cystistat be instilled into the bladder each week for 4-12 treatments and then monthly until symptoms resolve. The attending physician, urologist or radiologist should direct any prophylactic use of Cystistat®

PRECAUTIONS

Do not administer to patients with known hypersensitivity reactions
Discontinue use if adverse reactions are experienced
As no clinical evidence is available on the use of hyaluronic acid in children, pregnant and lactating women, treatment with Cystistat is not recommended in these patients

WARNING: KEEP OUT OF REACH OF CHILDREN.

Storage: Store at room temperature (15-30ºC). Do not freeze. Cystistat can be refrigerated, but should be returned to room temperature before being administered to a patient24

Supplied: 1 x 50ml vial of Cystistat 40mg. For single use only. Discard after use