2. Engelhardt PF, Morakis N, Daha LK et al. Long-term results of intravesical hyaluronan therapy in Bladder Pain Syndrome/Interstitial Cystitis. Int Urogynecol J 2011;22:401-405.

3. Constantinides C, Manousakas T, Nikolopoulos P et al. Prevention of recurrent bacterial cystitis by intravesical administration of hyaluronic acid: a pilot study. Br J Urol lnt 2004;93:1262-1266.

6. Cystistat Instructions For Use.

7. Raymond I, Vasdev N, Ferguson J et al. The clinical effectiveness of intravesical sodium hyaluronate (Cystistat) in patients with interstitial cystitis/painful bladder syndrome and recurrent urinary tract infections. Curr Urol 2012;6:93-98.

8. Teva UK Limited. Data on File. Mylan Global Sales Data. 2017.

9. Kallestrup EB, Jørgensen SS, Nordling J et al. Treatment of interstitial cystitis with Cystistat: A hyaluronic acid product. Scand J Urol Nephrol 2005;39:143-147.

10. Sommariva ML, Sandri SO & Ceriani V. Efficacy of sodium hyaluronate in the management of chemical and radiation cystitis. Minerva Urol Nefrol 2010;62:145-150.

11. Morales A, Emerson L, Nickel JC et al. Intravesical hyaluronic acid in the treatment of refractory interstitial cystitis. J Urol 1996;156:45-48.

12. Lipovac M, Kurz C, Reithmayr F et al. Prevention of recurrent bacterial urinary tract infections by intravesical instillation of hyaluronic acid. lnt J Gynaecol Obstet 2007;96:192-195.

13. Ahmad I, Sarath Krishna N & Meddings RN. Sequential hydrodistension and intravesical instillation of hyaluronic acid under general anaesthesia for treatment of refractory interstitial cystitis: a pilot study. lnt Urogynecol J 2007;19:543-546.

14. Nickel JC, Egerdie B, Downey J et al. A real-life multi-centre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis. BJU lnt 2009;103:56-60.

15. Nickel JC, Egerdie RB, Steinhoff G et al. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with interstitial cystitis/painful bladder syndrome. J Urol 2010;76:804-809.

16. Iavazzo C, Athanasiou S, Pitsouni E et al. Hyaluronic acid: An effective alternative treatment of interstitial cystitis, recurrent urinary tract infections, and hemorrhagic cystitis. Eur Urol 2007;51:1534-1541.

Cystistat is no longer recommended for use in Chemical-Induced Cystitis and this study included both Chemical-Induced and Radiation-Induced Cystitis.

What is Cystistat?


Temporarily replenishes your patients’ natural barrier against irritants in the bladder6

Effective in reducing pain, frequency and urgency and improving your patients’ quality of life7

With over 1 million instillations and 7 studies conducted worldwide, Cystistat brings you and your patients extensive experience in intravesical therapy2,3,8,9,10,11,12,13,14,15

How to use:
1 x Cystistat 50ml instillation: administered initially once weekly, for four to twelve consecutive weeks.6
Then once monthly until symptoms resolve.6
  • Sodium hyaluronate is a naturally occurring substance and is generally well tolerated by patients3,12,16